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- laugh and smile for no apparent reason
- speak very little, or not at all
- have severe intellectual disability and delayed development
- have problems with balance and movement, such as difficulty sitting up without support, walking with stiff legs and making jerky arm movements
- are restless and excitable
- need less sleep than most people, especially as children
- seizures
- a small head, which is flat at the back
- certain facial features, such as widely spaced teeth and eyes that look in different directions
- speech therapy
- occupational therapy
- physical therapy to improve posture, balance and movement